Dissecting non-canonical interactions in frameshift-stimulating mRNA pseudoknots.

  title={Dissecting non-canonical interactions in frameshift-stimulating mRNA pseudoknots.},
  author={Peter V Cornish and David P Giedroc and Mirko Hennig},
  journal={Journal of biomolecular NMR},
  volume={35 3},
A variety of powerful NMR experiments have been introduced over the last few years that allow for the direct identification of different combinations of donor and acceptor atoms involved in hydrogen bonds in biomolecules. This ability to directly observe tertiary structural hydrogen bonds in solution tremendously facilitates structural studies of nucleic acids. We show here that an adiabatic HNN-COSY pulse scheme permits observation and measurement of J(N,N) couplings for nitrogen sites that… CONTINUE READING