Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy.

@article{Shcherbata2007DissectingMA,
  title={Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy.},
  author={Halyna R Shcherbata and Andriy S. Yatsenko and Larissa B. Patterson and Vanita D Sood and Uri Nudel and David Yaffe and David Baker and Hannele Ruohola-Baker},
  journal={The EMBO journal},
  year={2007},
  volume={26 2},
  pages={
          481-93
        }
}
Perturbation in the Dystroglycan (Dg)-Dystrophin (Dys) complex results in muscular dystrophies and brain abnormalities in human. Here we report that Drosophila is an excellent genetically tractable model to study muscular dystrophies and neuronal abnormalities caused by defects in this complex. Using a fluorescence polarization assay, we show a high conservation in Dg-Dys interaction between human and Drosophila. Genetic and RNAi-induced perturbations of Dg and Dys in Drosophila cause cell… CONTINUE READING
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