Dissecting microregulation of a master regulatory network

  title={Dissecting microregulation of a master regulatory network},
  author={Amit U Sinha and Vivek Kaimal and Jing Chen and Anil G. Jegga},
  journal={BMC Genomics},
  pages={88 - 88}
The master regulator p53 tumor-suppressor protein through coordination of several downstream target genes and upstream transcription factors controls many pathways important for tumor suppression. While it has been reported that some of the p53's functions are microRNA-mediated, it is not known as to how many other microRNAs might contribute to the p53-mediated tumorigenesis. Here, we use bioinformatics-based integrative approach to identify and prioritize putative p53-regulated miRNAs, and… CONTINUE READING
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