Dissecting mRNA decay and translation inhibition during iron deficiency

@article{RamosAlonso2018DissectingMD,
  title={Dissecting mRNA decay and translation inhibition during iron deficiency},
  author={Luc{\'i}a Ramos-Alonso and Antonia Mar{\'i}a Romero and Julio Polaina and Sergi Puig and Mar{\'i}a Teresa Mart{\'i}nez-Pastor},
  journal={Current Genetics},
  year={2018},
  volume={65},
  pages={139-145}
}
Iron participates as a vital cofactor in multiple metabolic pathways. Despite its abundance, iron bioavailability is highly restricted in aerobic and alkaline environments. Therefore, living organisms have evolved multiple adaptive mechanisms to respond to iron scarcity. These strategies include a global remodeling of iron metabolism directed to optimize iron utilization. In the baker’s yeast Saccharomyces cerevisiae, this metabolic reorganization is accomplished to a large extent by an mRNA… CONTINUE READING
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