Dissecting functional roles of p53 N-terminal transactivation domains by microarray expression analysis.

@article{Ohki2007DissectingFR,
  title={Dissecting functional roles of p53 N-terminal transactivation domains by microarray expression analysis.},
  author={Rieko Ohki and Tatsuya Kawase and Tsutomu Ohta and Hitoshi Ichikawa and Yoichi Taya},
  journal={Cancer science},
  year={2007},
  volume={98 2},
  pages={189-200}
}
The p53 protein exerts its tumor suppressive function mainly by acting as a transcription activator. Two transactivation domains (TADs) located at the amino-terminus of p53 are required for transcription activation, and the activity of TADs is tightly regulated by post-translational modifications, such as phosphorylation. We attempted to dissect the functions of the two TADs and phosphorylation within the TADs by analyzing p53 target genes induced by full-length p53 (FL-p53), N-terminally… CONTINUE READING

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