Dissecting dynamin's role in clathrin-mediated endocytosis.

  title={Dissecting dynamin's role in clathrin-mediated endocytosis.},
  author={Marcel Mettlen and Thomas J. Pucadyil and Rajesh Ramachandran and Sandra L Schmid},
  journal={Biochemical Society transactions},
  volume={37 Pt 5},
The GTPase dynamin is essential for CME (clathrin-mediated endocytosis), but its exact function and mechanism of action have been controversial. Here, we review findings that have led to the current models for dynamin function, either as a mechanochemical enzyme driving membrane fission or as a regulatory GTPase monitoring rate-limiting steps in CME. However, these models are not mutually exclusive and subsequent studies have provided evidence for both dynamin functions. Recent evidence derived… CONTINUE READING
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A partnership between dynamics and lipids defines dynamics and intermediates of membrane fission

  • P. V. Bashkirov, S. A. Akimov, A. I. Evseev, S. L. Schmid, J. Zimmerberg, V. A. Frolov
  • 2008

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