Dissecting demyelination

  title={Dissecting demyelination},
  author={R. Miller and S. Mi},
  journal={Nature Neuroscience},
  • R. Miller, S. Mi
  • Published 2007
  • Medicine
  • Nature Neuroscience
  • The loss of central nervous system myelin and the failure of remyelination by oligodendrocytes contribute to the functional impairment that characterizes diseases such as multiple sclerosis. Why myelin repair fails in multiple sclerosis is currently unclear; however, new understanding of the generation of oligodendrocytes and myelination during development, as well as an increasing understanding of the bases of successful remyelination, are providing new insights and therapeutic targets. We… CONTINUE READING
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