Dissecting a regulatory calcium-binding site of CLC-K kidney chloride channels

@inproceedings{Gradogna2012DissectingAR,
  title={Dissecting a regulatory calcium-binding site of CLC-K kidney chloride channels},
  author={Antonella Gradogna and Cristina Fenollar-Ferrer and Lucy R. Forrest and Michael Pusch},
  booktitle={The Journal of general physiology},
  year={2012}
}
The kidney and inner ear CLC-K chloride channels, which are involved in salt absorption and endolymph production, are regulated by extracellular Ca(2+) in the millimolar concentration range. Recently, Gradogna et al. (2010. J. Gen. Physiol. http://dx.doi.org/10.1085/jgp.201010455) identified a pair of acidic residues (E261 and D278) located in the loop between helices I and J as forming a putative intersubunit Ca(2+)-binding site in hClC-Ka. In this study, we sought to explore the properties of… CONTINUE READING

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