Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor

@article{Straight2003DissectingTA,
  title={Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor},
  author={Aaron F. Straight and Amy Cheung and John Limouze and Irene Chen and Nicholas James Westwood and James R. Sellers and Timothy J. Mitchison},
  journal={Science},
  year={2003},
  volume={299},
  pages={1743 - 1747}
}
Completion of cell division during cytokinesis requires temporally and spatially regulated communication from the microtubule cytoskeleton to the actin cytoskeleton and the cell membrane. We identified a specific inhibitor of nonmuscle myosin II, blebbistatin, that inhibited contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Using blebbistatin and other drugs, we showed that exit from the cytokinetic phase of the cell cycle depends on ubiquitin-mediated… 

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