Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.

@article{Lacoste2002DisruptorOT,
  title={Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.},
  author={Nicolas Lacoste and Rhea T. Utley and Joanna M. Hunter and Guy G. Poirier and Jacques C{\^o}t{\'e}},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 34},
  pages={30421-4}
}
Yeast disruptor of telomeric silencing-1 (DOT1) is involved in gene silencing and in the pachytene checkpoint during meiotic cell cycle. Here we show that the Dot1 protein possesses intrinsic histone methyltransferase (HMT) activity. When compared with Rmt1, another putative yeast HMT, Dot1 shows very distinct substrate specificity. While Rmt1 methylates histone H4, Dot1 targets histone H3. In contrast to Rmt1, which can only modify free histones, Dot1 activity is specific to nucleosomal… CONTINUE READING