Disruption of white matter integrity in bipolar depression as a possible structural marker of illness.

@article{Benedetti2011DisruptionOW,
  title={Disruption of white matter integrity in bipolar depression as a possible structural marker of illness.},
  author={Francesco Benedetti and Ping-Hong Yeh and Marcella Bellani and Daniele Radaelli and Mark A Nicoletti and Sara Poletti and Andrea Falini and Sara Dallaspezia and Cristina Colombo and Giuseppe Scotti and Enrico Smeraldi and Jair C. Soares and Paolo Brambilla},
  journal={Biological psychiatry},
  year={2011},
  volume={69 4},
  pages={309-17}
}
BACKGROUND Diffusion tensor imaging allows the study of integrity of white matter (WM) tracts. Literature suggests that WM integrity could be altered in bipolar disorder. Heterogeneity of brain imaging methods, the studied samples, and drug treatments make localization, nature, and severity of the WM abnormalities unclear. METHODS We applied tract-based spatial statistics of diffusion tensor imaging measures to compare fractional anisotropy (FA), mean, and radial diffusivity of the WM… CONTINUE READING
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