Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.

  title={Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.},
  author={C. Heinze and Anika Seniuk and Maxim V Sokolov and Antje K. Huebner and Agnieszka E Klementowicz and Istv{\'a}n Andr{\'a}s Szij{\'a}rt{\'o} and Johanna Schleifenbaum and Helga Vitzthum and Maik Gollasch and Heimo Ehmke and Bj{\"o}rn Christian Schroeder and Christian Andreas H{\"u}bner},
  journal={The Journal of clinical investigation},
  volume={124 2},
High blood pressure is the leading risk factor for death worldwide. One of the hallmarks is a rise of peripheral vascular resistance, which largely depends on arteriole tone. Ca2+-activated chloride currents (CaCCs) in vascular smooth muscle cells (VSMCs) are candidates for increasing vascular contractility. We analyzed the vascular tree and identified substantial CaCCs in VSMCs of the aorta and carotid arteries. CaCCs were small or absent in VSMCs of medium-sized vessels such as mesenteric… CONTINUE READING


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