Disruption of tight junction structure in salivary glands from Sjögren's syndrome patients is linked to proinflammatory cytokine exposure.

@article{Ewert2010DisruptionOT,
  title={Disruption of tight junction structure in salivary glands from Sj{\"o}gren's syndrome patients is linked to proinflammatory cytokine exposure.},
  author={Patricia Ewert and Sergio Aguilera and Cecilia Alliende and Yoon-Jeoung Kwon and Amelina Albornoz and Claudio Molina and Ulises Urzua and Andrew F. G. Quest and Nancy Olea and Paola K. Perez and Isabel Samila Lima Castro and Mar{\'i}a-Jos{\'e} Barrera and R. Harold A. Romo and Marcela Alejandra Hermoso and Cecilia Leyton and M. Julieta Gonz{\'a}lez},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 5},
  pages={1280-9}
}
OBJECTIVE Disorganization of acinar cell apical microvilli and the presence of stromal collagen in the acinar lumen suggest that the labial salivary gland (LSG) barrier function is impaired in patients with Sjögren's syndrome. Tight junctions define cell polarity and regulate the paracellular flow of ions and water, crucial functions of acinar cells. This study was undertaken to evaluate the expression and localization of tight junction proteins in LSGs from patients with SS and to determine in… CONTINUE READING
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