Disruption of the talin gene arrests mouse development at the gastrulation stage.

@article{Monkley2000DisruptionOT,
  title={Disruption of the talin gene arrests mouse development at the gastrulation stage.},
  author={Susan J. Monkley and X. H. Zhou and Sarah Kinston and Susan M. Giblett and Lance Hemmings and Helen Priddle and Jane E. Brown and Catrin A. Pritchard and David R. Critchley and Reinhard F{\"a}ssler},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2000},
  volume={219 4},
  pages={560-74}
}
Studies on cultured cells show that the cytoskeletal protein talin plays a key role in cell spreading and the assembly of cell-extracellular matrix junctions. To examine the role of talin in vivo, we have generated mice with a targeted disruption of the talin gene. Heterozygotes are normal, but no surviving homozygous mutant animals were obtained, proving that talin is required for embryogenesis. Mutant embryos develop normally to the blastocyst stage and implant, but there is a gross… CONTINUE READING