Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects.

@article{Steenbergen2005DisruptionOT,
  title={Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects.},
  author={Rineke Steenbergen and Terry S Nanowski and Anne Beigneux and Agnes Kulinski and Stephen G. Young and Jean E. Vance},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 48},
  pages={40032-40}
}
Most of the phosphatidylethanolamine (PE) in mammalian cells is synthesized by two pathways, the CDP-ethanolamine pathway and the phosphatidylserine (PS) decarboxylation pathway, the final steps of which operate at spatially distinct sites, the endoplasmic reticulum and mitochondria, respectively. We investigated the importance of the mitochondrial pathway for PE synthesis in mice by generating mice lacking PS decarboxylase activity. Disruption of Pisd in mice resulted in lethality between days… CONTINUE READING