Disruption of the pelota gene causes early embryonic lethality and defects in cell cycle progression.

@article{Adham2003DisruptionOT,
  title={Disruption of the pelota gene causes early embryonic lethality and defects in cell cycle progression.},
  author={Ibrahim Mohamed Adham and Mahmoud A. A. Sallam and Gerd Steding and Monika Korabiowska and Ulrich Brinck and Sigrid Hoyer-Fender and Changkyu Oh and Wolfgang F. Engel},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 4},
  pages={
          1470-6
        }
}
Mutations in either the Drosophila melanogaster pelota or pelo gene or the Saccharomyces cerevisiae homologous gene, DOM34, cause defects of spermatogenesis and oogenesis in Drosophila, and delay of growth and failure of sporulation in yeast. These phenotypes suggest that pelota is required for normal progression of the mitotic and meiotic cell cycle. To determine the role of the pelota in mouse development and progression of cell cycle, we have established a targeted disruption of the mouse… CONTINUE READING

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Molecular cloning, expression and chromosomal localization of the human pelota gene

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