Disruption of the oxysterol 7alpha-hydroxylase gene in mice.

  title={Disruption of the oxysterol 7alpha-hydroxylase gene in mice.},
  author={Jia Li-Hawkins and Erik G. Lund and Stephen D. Turley and D. W. Russell},
  journal={The Journal of biological chemistry},
  volume={275 22},
Mice without oxysterol 7alpha-hydroxylase, an enzyme of the alternate bile acid synthesis pathway with a sexually dimorphic expression pattern, were constructed by the introduction of a null mutation at the Cyp7b1 locus. Animals heterozygous (Cyp7b1(+/-)) and homozygous (Cyp7b1(-/-)) for this mutation were grossly indistinguishable from wild-type mice. Plasma and tissue levels of 25- and 27-hydroxycholesterol, two oxysterol substrates of this enzyme with potent regulatory actions in cultured… CONTINUE READING
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