Disruption of the nucleosomes at the replication fork.

@article{Gruss1993DisruptionOT,
  title={Disruption of the nucleosomes at the replication fork.},
  author={Claudia Gruss and Jiansheng Wu and T. Koller and J. M. Sogo},
  journal={The EMBO journal},
  year={1993},
  volume={12 12},
  pages={
          4533-45
        }
}
The fate of parental nucleosomes during chromatin replication was studied in vitro using in vitro assembled chromatin containing the whole SV40 genome as well as salt-treated and native SV40 minichromosomes. In vitro assembled minichromosomes were able to replicate efficiently in vitro, when the DNA was preincubated with T-antigen, a cytosolic S100 extract and three deoxynucleoside triphosphates prior to chromatin assembly, indicating that the origin has to be free of nucleosomes for… CONTINUE READING
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