Disruption of the myocardial extracellular matrix leads to cardiac dysfunction.

@article{Kim2000DisruptionOT,
  title={Disruption of the myocardial extracellular matrix leads to cardiac dysfunction.},
  author={H. Kim and S. Dalal and E. Young and M. Legato and M. Weisfeldt and J. D’Armiento},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={106 7},
  pages={
          857-66
        }
}
MMP activity with disruption of structural collagen has been implicated in the pathophysiology of dilated cardiomyopathy. To examine the role of this enzyme in cardiac function, a transgenic mouse was created that constitutively expressed human collagenase (MMP-1) in the heart. At 6 months of age, these animals demonstrated compensatory myocyte hypertrophy with an increase in the cardiac collagen concentration due to elevated transcription of type III collagen. Chronic myocardial expression of… Expand
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