Disruption of the murine PIASx gene results in reduced testis weight.

  title={Disruption of the murine PIASx gene results in reduced testis weight.},
  author={Henrikki Santti and Laura Mikkonen and Ajay Anand and Sirpa J. Hirvonen-Santti and Jorma Toppari and Markus Panhuysen and Franz Vauti and Marzia Perera and Giorgio La Corte and Wolfgang Wurst and Olli A. J{\"a}nne and Jorma J. Palvimo},
  journal={Journal of molecular endocrinology},
  volume={34 3},
PIASx belongs to the PIAS protein family, the members of which modulate activities of several transcription factors and act as E3 ligases in the sumoylation pathway. The PIASx gene is highly expressed in testis, suggesting a role in spermatogenesis. To investigate the function of PIASx in vivo, we have disrupted the PIASx gene in mice. Interestingly, the knockout mice were viable and fertile. Despite the normal fertility, the testis weight of the mutant animals was reduced and their number of… CONTINUE READING