Disruption of the murine IL-4 gene blocks Th2 cytokine responses

Abstract

MURINE T-helper clones are classified into two distinct subsets (Thl and Th2) on the basis of their patterns of lymphokine secretion. Thl clones secrete interleukin-2 (IL-2), tumour necrosis factor-β (TNF-β) and interferon-γ (IFN-γ), whereas Th2 clones secrete IL-4, IL-5 and IL-10 (ref. 1). These subsets are reciprocally regulated by IL-4, IL-10 and IFN… (More)
DOI: 10.1038/362245a0

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