Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate.


Development of the secondary palate in mammals is a complex process that can be easily perturbed, leading to the common and distressing birth defect cleft palate. Animal models are particularly useful tools for dissecting underlying genetic components of cleft palate. We describe a new cleft palate model resulting from a transgene insertion mutation… (More)
DOI: 10.1597/09-145