Disruption of the kinin B1 receptor gene affects potentiating effect of captopril on BK-induced contraction in mice stomach fundus.

@article{Barbosa2006DisruptionOT,
  title={Disruption of the kinin B1 receptor gene affects potentiating effect of captopril on BK-induced contraction in mice stomach fundus.},
  author={Ana M R B Barbosa and Sandra A Felipe and Jo{\~a}o Bosco Pesquero and A. C. M. Paiva and Suma Imura Shimuta},
  journal={Peptides},
  year={2006},
  volume={27 12},
  pages={3377-82}
}
A transgenic mouse model, deficient in kinin B(1) receptor (B(1)(-/-)) was used to evaluate the role of B(2) receptor in the smooth muscle stomach fundus. The results showed that the potency of bradykinin (BK) to induce contraction in the gastric tissue was maintained whereas the efficacy was markedly reduced. The angiotensin converting enzyme (ACE) inhibitor captopril potentiated BK-induced effect in wild type (WT) but not in B(1)(-/-) fundus. However, ACE activity detected by the convertion… CONTINUE READING