Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate.

@article{FornerPiquer2018DisruptionOT,
  title={Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate.},
  author={Isabel Forner-Piquer and Stefania Santangeli and Francesca Maradonna and Alessandro Rabbito and Fabiana Piscitelli and Hamid R. Habibi and Vincenzo Di Marzo and Oliana Carnevali},
  journal={Environmental pollution},
  year={2018},
  volume={241},
  pages={
          1-8
        }
}
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26 Citations
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26 Citations

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Citation Type

Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary
TLDR
It is demonstrated that follicular atresia can occur after exposure to environmental levels of DiNP for 21 days, which may adversely affect the reproductive performance of female zebrafish in a non-monotonic manner.
Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system.
Effects of diisononyl phthalate (DiNP) on the endocannabinoid and reproductive systems of male gilthead sea bream (Sparus aurata) during the spawning season
TLDR
The results clearly suggest a negative effect of DiNP via the diet on the male endocrine system of gilthead sea bream during the reproductive season.
17α-ethinyl estradiol induces behavioral and reproductive damages in zebrafish (Danio rerio)
TLDR
The EE2 caused the reduction of the exploratory activity of the animals, when observed the behavior, and an acceleration of the maturation process of the oocytes evaluated in the histological analysis, highlighting the concern about the potential risks it may cause to the aquatic biota.
Di-isononyl Phthalate (DINP) Impairs Reproduction in the Freshwater Fish, Oreochromis mossambicus (Peters 1852)
TLDR
DINP altered the normal ovarian and testicular steroidogenesis thereby impairs reproduction of fish and the inhibitory effect of DINP on antioxidant enzymes increases with time, indicating the induction of oxidative stress in gonads.
Detrimental effects induced by diisononyl phthalate on development and behavior of Drosophila larva and potential mechanisms.
Effects of Dietary Bisphenol A on the Reproductive Function of Gilthead Sea Bream (Sparus aurata) Testes
TLDR
Interestingly, the levels of endocannabinoids and endoc cannabinoidoid-like compounds were significantly reduced after both treatments, and a few changes were noticed in the expression of genes coding for ECS enzymes, while the receptors were up-regulated depending on the BPA dose.
Exposure evaluation of diisononyl phthalate in the adults of Drosophila melanogaster: Potential risks in fertility, lifespan, behavior, and modes of action.
Endocrine disruptor responses in African sharptooth catfish (Clarias gariepinus) exposed to di-(2-ethylhexyl)-phthalate.
DEHP and DINP Induce Tissue- and Gender-Specific Disturbances in Fatty Acid and Lipidomic Profiles in Neonatal Mice: A Comparative Study.
TLDR
It is demonstrated that exposure of neonatal mice to DEHP and DINP at a daily dose of 0.048 or 4.8 mg/kg from postnatal day 0 (PND0) to PND21 caused non-monotonic, as well as tissue- and gender-specific, alterations of total fatty acid compositions in plasma, heart and adipose tissues.
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References

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Dose‐Specific Effects of Di‐Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish
TLDR
The results demonstrate that DiNP upregulates orexigenic signals and causes hepatosteatosis together with deregulation of the peripheral ECS and lipid metabolism, and suggest that replacement of DEHP with DiNP should be considered with caution because of observed adverse DiNP effects on aquatic organisms.
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TLDR
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TLDR
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TLDR
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