Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae.

@article{Schjerling1996DisruptionOT,
  title={Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae.},
  author={C K Schjerling and R G Hummel and Johanna K Hansen and C Borsting and Jan M\oller Mikkelsen and Karsten Kristiansen and Jens Knudsen},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 37},
  pages={22514-21}
}
The ACB1 gene encoding the acyl-CoA-binding protein (ACBP) was disrupted in Saccharomyces cerevisiae. The disruption did not affect the growth rate on glucose but reduced the growth rate on ethanol slightly. Although the growth rate of the acb1-disrupted cells was unaffected or only slightly affected, the acb1-disrupted strain was unable to compete with wild type cells when grown in mixed culture. The acyl-CoA level in the disrupted cells was increased from 1.5- to 2.5-fold during exponential… CONTINUE READING

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