Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.

Abstract

Huntingtin interacting protein 1 (HIP1) is a recently identified component of clathrin-coated vesicles that plays a role in clathrin-mediated endocytosis. To explore the normal function of HIP1 in vivo, we created mice with targeted mutation in the HIP1 gene (HIP1(-/-)). HIP1(-/-) mice develop a neurological phenotype by 3 months of age manifest with a… (More)

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Cite this paper

@article{Metzler2003DisruptionOT, title={Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.}, author={Martina Metzler and Bo Li and Lu Gan and John Georgiou and Claire-Anne Gutekunst and Yushan Wang and Enrique de la Torre and Rebecca S. Devon and Rosemary Oh and Val{\'e}rie Legendre-Guillemin and Mark Rich and Christine M. Alvarez and Marina Gertsenstein and Peter S McPherson and Andr{\'a}s Nagy and Yu Tian Wang and John C. C. Roder and Lynn A Raymond and Michael R. Hayden}, journal={The EMBO journal}, year={2003}, volume={22 13}, pages={3254-66} }