Disruption of the cortical actin cytoskeleton does not affect store operated Ca2+ channels in human T-cells.

@article{Mller2007DisruptionOT,
  title={Disruption of the cortical actin cytoskeleton does not affect store operated Ca2+ channels in human T-cells.},
  author={Philipp A. M{\"u}ller and Ariel Quintana and D{\'e}sir{\'e}e Griesemer and Markus Hoth and Jean Pieters},
  journal={FEBS letters},
  year={2007},
  volume={581 18},
  pages={3557-62}
}
Lymphocyte signaling and activation leads to the influx of extracellular Ca(2+) via the activation of Ca(2+) release activated Ca(2+) (CRAC) channels in the plasma membrane. Activation of CRAC channels occurs following emptying of the endoplasmic reticulum intracellular Ca(2+) stores. One model to explain the coupling of store-emptying to CRAC activation is the secretion-like conformational coupling model. This model proposes that store depletion increases junctions between the endoplasmic… CONTINUE READING

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