Disruption of the arsenic (+3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention of orally administered arsenate.

@article{Drobn2009DisruptionOT,
  title={Disruption of the arsenic (+3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention of orally administered arsenate.},
  author={Zuzana Drobn{\^a} and Hua Naranmandura and Kevin M. Kubachka and Brenda C. Edwards and Karen M Herbin-Davis and Miroslav Stỳblo and Xuan Bach Le and John T. Creed and Noboyu Maeda and Michael F Hughes and David J Thomas},
  journal={Chemical research in toxicology},
  year={2009},
  volume={22 10},
  pages={
          1713-20
        }
}
The arsenic (+3 oxidation state) methyltransferase (As3mt) gene encodes a 43 kDa protein that catalyzes methylation of inorganic arsenic. Altered expression of AS3MT in cultured human cells controls arsenic methylation phenotypes, suggesting a critical role in arsenic metabolism. Because methylated arsenicals mediate some toxic or carcinogenic effects linked to inorganic arsenic exposure, studies of the fate and effects of arsenicals in mice which cannot methylate arsenic could be instructive… CONTINUE READING
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