Disruption of the actin cytoskeleton up-regulates iNOS expression in vascular smooth muscle cells.


Cytokines and bacterial lipopolysaccharide (LPS) induce the expression of inducible nitric oxide synthase (iNOS), resulting in the release of nitric oxide (NO) from vascular smooth muscle cells. We here demonstrated that disruption of F-actin formation by sequestration of G-actin with the toxin latrunculin B (Lat B) dramatically potentiated LPS-induced iNOS… (More)


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