Disruption of the Shc/Grb2 Complex during Abelson Virus Transformation Affects Proliferation, but Not Apoptosis

@article{Baughn2005DisruptionOT,
  title={Disruption of the Shc/Grb2 Complex during Abelson Virus Transformation Affects Proliferation, but Not Apoptosis},
  author={Linda B. Baughn and Naomi E. Rosenberg},
  journal={Journal of Virology},
  year={2005},
  volume={79},
  pages={2325 - 2334}
}
ABSTRACT The v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) induces pre-B-cell transformation. Signals emanating from the SH2 domain of the protein are required for transformation, and several proteins bind this region of v-Abl. One such protein is the adaptor molecule Shc, a protein that complexes with Grb2/Sos and facilitates Ras activation, an event associated with Ab-MLV transformation. To test the role this interaction plays in growth and survival of… 
SH2-Containing Inositol 5′-Phosphatase Inhibits Transformation of Abelson Murine Leukemia Virus
TLDR
It is shown that v-Abl expression reduces levels of full-length p145 SHIP in a v- abl kinase activity-dependent fashion, which is a critical component in Ab-MLV transformation.
SH 2-Containing Inositol 5-Phosphatase Inhibits Transformation of Abelson Murine Leukemia Virus †
TLDR
It is shown that v-Abl expression reduces levels of full-length p145 SHIP in a v- Abl kinase activity-dependent fashion, which is a critical component in Ab-MLV transformation.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Deregulation of Signal Transduction Pathways by Oncogenic Retroviruses
TLDR
The effects of oncogenic retroviruses on signal transduction pathways will be reviewed for four oncogenes: Abelson murine leukemia virus, S13 avian erythroblastosis virus, Friend spleen focus-forming virus, and Jaagsiekte sheep retrovirus.
Insulin-like Growth Factor-I Stimulates Shc-dependent Phosphatidylinositol 3-Kinase Activation via Grb2-associated p85 in Vascular Smooth Muscle Cells*
TLDR
It is concluded that in VSMCs exposed to hyperglycemia, IGF-I stimulation of Shc facilitates the transfer of Grb2 to p85 resulting in enhanced PI3K activation and AKT phosphorylation leading to enhanced cell proliferation and migration.
Computational Theory of Biological Function I — The Kinematics of Molecular Trees
TLDR
A language for efficiently representing the function of protein-like molecules in a cell, in a formal languagewhich describes the data and algorithm, not the physical motions of the parts, is built.
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TLDR
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