Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis.

  title={Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis.},
  author={Piyali Dasgupta and Jiazhi Sun and Sheng Wang and Gina Fusaro and Vicki Betts and Jaya Padmanabhan and Sa{\"i}d M. Sebti and Srikumar Chellappan},
  journal={Molecular and cellular biology},
  volume={24 21},
The retinoblastoma tumor suppressor protein (Rb) plays a vital role in regulating mammalian cell cycle progression and inactivation of Rb is necessary for entry into S phase. Rb is inactivated by phosphorylation upon growth factor stimulation of quiescent cells, facilitating the transition from G(1) phase to S phase. Although the signaling events after growth factor stimulation have been well characterized, it is not yet clear how these signals contact the cell cycle machinery. We had found… CONTINUE READING


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