Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency.


Although the RAG2 core domain is the minimal region required for V(D)J recombination, the noncore region also plays important roles in the regulation of recombination, and mutations in this region are often related to severe combined immunodeficiency. A complete understanding of the functions of the RAG2 noncore region and the potential contributions of its… (More)
DOI: 10.1002/eji.201545896