Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.

@article{Berger2010DisruptionOT,
  title={Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.},
  author={Thorsten Berger and Carol Cy Cheung and Andrew James Elia and Tak W Mak},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 7},
  pages={2995-3000}
}
Based largely on studies in xenograft models, lipocalin-2 (Lcn2) has been implicated in the progression of multiple types of human tumors, including breast cancer. Here we examine the role of Lcn2 in mammary tumorigenesis and lung metastasis using an in vivo molecular genetics approach. We crossed a well-characterized transgenic mouse model of breast cancer, the MMTV-PyMT (mouse mammary tumor virus-polyoma middle T antigen) mouse, with two independent gene-targeted Lcn2(-/-) mouse strains of… CONTINUE READING

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