Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

@article{Rodig1998DisruptionOT,
  title={Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses},
  author={Scott J. Rodig and Marco Antonio Meraz and J.Michael White and Patricia A. Lampe and Joan K. Riley and Cora D. Arthur and Kathleen L. King and Kathleen C.F. Sheehan and Li Yin and Diane Pennica and Eugene M. Johnson and Robert D. Schreiber},
  journal={Cell},
  year={1998},
  volume={93},
  pages={373-383}
}

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Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

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Therapeutic targeting of Janus kinases

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Function of JAKs and STATs in Lymphocytes: Bench to Bedside

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Generation of Janus kinase 1 (JAK1) conditional knockout mice

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References

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Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

Defective Lymphoid Development in Mice Lacking Jak3

Jak3 plays a critical role in γc signaling and lymphoid development in thymocytes and severe B cell and T cell lymphopenia similar to severe combined immunodeficiency disease (SCID).

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

Data demonstrate that Jak3 is critical for the progression of B cell development in the bone marrow and for the functional competence of mature T cells.

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.

Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak- Tyk phosphorylation in different cell lines.

Interleukin-6 family of cytokines and gp130.

It is shown that IL-6, together with IL-3, induces the expansion of murine hematopoietic progenitor cells and to be responsible for stimulating resting cells to enter the Cl-phase, a fact that may explain the redundant activities of IL- 6 and LIF.

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

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    Proceedings of the National Academy of Sciences of the United States of America
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Results indicate that gp130 plays a crucial role in myocardial development and hematopoiesis during embryogenesis and some gp130-/- embryos show anemia due to impaired development of erythroid lineage cells.