Disruption of the Cytoskeleton After Apoptosis Induction with Autoantibodies

  title={Disruption of the Cytoskeleton After Apoptosis Induction with Autoantibodies},
  author={I. Boehm},
  pages={183 - 189}
  • I. Boehm
  • Published 2003
  • Medicine, Biology
  • Autoimmunity
  • F-actin cleavage was studied in PBMC after treatment with anti-dsDNA antibodies. Significant changes in F-actin disruption detected by decrease of FITC-phalloidin staining occurred after apoptosis induction with anti-dsDNA antibodies ( p<0.006). Despite of similar F-actin disruption, the switch of phosphatidylserine (PS) to the outer leaflet of the cell membrane as detected by annexin V binding was lower after anti-dsDNA antibody than without antibody treatment (58.4±11.0% vs. 81.9±7.7%). F… CONTINUE READING
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