Disruption of the Cox-1 gene slows repair of microscopic lesions in the mouse gastric epithelium.

@article{Starodub2008DisruptionOT,
  title={Disruption of the Cox-1 gene slows repair of microscopic lesions in the mouse gastric epithelium.},
  author={Olga T Starodub and Elise S. Demitrack and Heidi K. Baumgartner and Marshall H Montrose},
  journal={American journal of physiology. Cell physiology},
  year={2008},
  volume={294 1},
  pages={C223-32}
}
Cyclooxygenase-1 (Cox-1) contributes to gastric defense of healthy tissue, but the role in the protection of the gastric epithelium after minor, acute damage has been difficult to study in vivo. Using 710-nm two-photon light absorption to create microscopic gastric damage in anesthetized mice with the gastric mucosal surface surgically exposed and perfused… CONTINUE READING