Disruption of the Candida albicans CYB5 gene results in increased azole sensitivity.

Abstract

Sterol synthesis in fungi is an aerobic process requiring molecular oxygen and, for several cytochrome-mediated reactions, aerobically synthesized heme. Cytochrome b(5) is required for sterol C5-6 desaturation and the encoding gene, CYB5, is nonessential in Saccharomyces cerevisiae. Cyb5p and Ncp1p (cytochrome P-450 reductase) appear to have overlapping… (More)

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Cite this paper

@article{Rogers2004DisruptionOT, title={Disruption of the Candida albicans CYB5 gene results in increased azole sensitivity.}, author={Kristina M Rogers and Charles Pierson and Nicholas T Culbertson and Caiqing Mo and Aaron M Sturm and John Eckstein and Robert J. Barbuch and N. Douglas Lees and Martin Bard}, journal={Antimicrobial agents and chemotherapy}, year={2004}, volume={48 9}, pages={3425-35} }