Disruption of the Candida albicans ATC1 gene encoding a cell-linked acid trehalase decreases hypha formation and infectivity without affecting resistance to oxidative stress.

@article{Pedreo2007DisruptionOT,
  title={Disruption of the Candida albicans ATC1 gene encoding a cell-linked acid trehalase decreases hypha formation and infectivity without affecting resistance to oxidative stress.},
  author={Yolanda Pedre{\~n}o and Pilar G{\'o}nzalez-P{\'a}rraga and Mar{\'i}a Concepci{\'o}n Mart{\'i}nez-Esparza and R. Sentandreu and E. Valentin and J A Arg{\"u}elles},
  journal={Microbiology},
  year={2007},
  volume={153 Pt 5},
  pages={1372-81}
}
In Candida albicans, the ATC1 gene, encoding a cell wall-associated acid trehalase, has been considered as a potentially interesting target in the search for new antifungal compounds. A phenotypic characterization of the double disruptant atc1Delta/atc1Delta mutant showed that it was unable to grow on exogenous trehalose as sole carbon source. Unlike actively growing cells from the parental strain (CAI4), the atc1Delta null mutant displayed higher resistance to environmental insults, such as… CONTINUE READING

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