Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide.

@article{Lvesque2003DisruptionOT,
  title={Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide.},
  author={Jean Pierre L{\'e}vesque and Jean Hendy and Yasushi Takamatsu and Paul J. Simmons and Linda J Bendall},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={111 2},
  pages={187-96}
}
Hematopoietic progenitor cells (HPCs) normally reside in the bone marrow (BM) but can be mobilized into the peripheral blood (PB) after treatment with GCSF or chemotherapy. In previous studies, we showed that granulocyte precursors accumulate in the BM during mobilization induced by either GCSF or cyclophosphamide (CY), leading to the accumulation of active neutrophil proteases in this tissue. We now report that mobilization of HPCs by GCSF coincides in vivo with the cleavage of the N-terminus… CONTINUE READING
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