Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation.

@article{Coli2009DisruptionOS,
  title={Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation.},
  author={Sandra Coli{\'e} and Paul P Van Veldhoven and Blandine Kedjouar and Carmen Bedia and Virginie Albinet and S. Sorli and Virginie Garcia and Mojgan Djavaheri-Mergny and Chantal Bauvy and Patrice Codogno and Thierry Levade and Nathalie Andrieu-Abadie},
  journal={Cancer research},
  year={2009},
  volume={69 24},
  pages={
          9346-53
        }
}
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in cancer development through stimulation of cell survival, proliferation, migration, and angiogenesis. Irreversible degradation of S1P is catalyzed by S1P lyase (SPL). The human SGPL1 gene that encodes SPL maps to a region often mutated in cancers. To investigate the effect of SPL deficiency on cell survival and transformation, the susceptibility to anticancer drugs of fibroblasts generated from SPL-deficient mouse… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Similar Papers

Loading similar papers…