Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis

@article{Russell2013DisruptionOS,
  title={Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis},
  author={Aaron P Russell and Shogo Wada and Lodovica Vergani and M. Benjamin Hock and Takayuki Akimoto},
  journal={Neurobiology of Disease},
  year={2013},
  volume={49},
  pages={107-117}
}
Skeletal muscle mitochondrial dysfunction is believed to play a role in the progression and severity of amyotrophic lateral sclerosis (ALS). The regulation of transcriptional co-activators involved in mitochondrial biogenesis and function in ALS is not well known. When compared with healthy control subjects, patients with ALS, but not neurogenic disease (ND), had lower levels of skeletal muscle peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) mRNA and protein and estrogen… CONTINUE READING

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