Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1.

@article{McCaffrey1999DisruptionOR,
  title={Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1.},
  author={Joy L McCaffrey and Lili Yamasaki and Nicholas J. Dyson and E E Harlow and Anne E. Griep},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 9},
  pages={6458-68}
}
Complexes between the retinoblastoma protein (pRb) and the transcription factor E2F-1 are thought to be important for regulating cell proliferation. We have shown previously that the E7 oncoprotein from human papillomavirus type 16, dependent upon its binding to pRb proteins, induces proliferation, disrupts differentiation, and induces apoptosis when expressed in the differentiating, or fiber, cells of the ocular lenses in transgenic mice. Mice that carry a null mutation in E2F-1 do not exhibit… CONTINUE READING

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