Disruption of redox homeostasis and carcinogen metabolizing enzymes changes by administration of vitamin E to rats.

@article{Vivarelli2016DisruptionOR,
  title={Disruption of redox homeostasis and carcinogen metabolizing enzymes changes by administration of vitamin E to rats.},
  author={Fabio Vivarelli and Donatella Canistro and Paola Franchi and Andrea Sapone and Andrea Vornoli and Clara Maria Della Croce and Vincenzo Longo and Marco Lucarini and M. Paolini},
  journal={Life sciences},
  year={2016},
  volume={145},
  pages={166-73}
}
AIMS A large meta-analysis of randomized clinical trials has seriously questioned chemoprevention based on vitamins including vitamin E (VE), and an increased risk for cancer among long-term users was actually seen. However, the mechanism underlying these findings still remain unknown. To clarify the mechanism, in an in vivo model we studied the putative disruption of redox homeostasis and the perturbation of carcinogen metabolizing enzymes determined by VE. MAIN METHODS Male Sprague-Dawley… CONTINUE READING