Disruption of protein quality control in Parkinson's disease.

  title={Disruption of protein quality control in Parkinson's disease.},
  author={Casey N. Cook and Caroline T. Stetler and Leonard Petrucelli},
  journal={Cold Spring Harbor perspectives in medicine},
  volume={2 5},
Parkinson's disease (PD), like a number of neurodegenerative diseases associated with aging, is characterized by the abnormal accumulation of protein in a specific subset of neurons. Although researchers have recently elucidated the genetic causes of PD, much remains unknown about what causes increased protein deposition in the disease. Given that increased protein aggregation may result not only from an increase in production, but also from decreased protein clearance, it is imperative to… CONTINUE READING
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