Disruption of prepulse inhibition in mice lacking mGluR1.

@article{Brody2003DisruptionOP,
  title={Disruption of prepulse inhibition in mice lacking mGluR1.},
  author={Stuart Brody and François Conquet and Mark A. Geyer},
  journal={The European journal of neuroscience},
  year={2003},
  volume={18 12},
  pages={3361-6}
}
Sensorimotor gating, measured by prepulse inhibition of the startle response (PPI), is a cross-species form of information processing that is deficient in patients with schizophrenia and is widely used as a model to study the neurobiology of this disorder. The eight known metabotropic glutamate receptors (mGluRs) are divided into three groups on the basis of sequence homology and pharmacological properties. Group I consists of mGluR5 and mGluR1, both of which are coupled positively to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

Similar Papers

Loading similar papers…