Disruption of prepulse inhibition in mice lacking mGluR1.

  title={Disruption of prepulse inhibition in mice lacking mGluR1.},
  author={Stuart Brody and François Conquet and Mark A. Geyer},
  journal={The European journal of neuroscience},
  volume={18 12},
Sensorimotor gating, measured by prepulse inhibition of the startle response (PPI), is a cross-species form of information processing that is deficient in patients with schizophrenia and is widely used as a model to study the neurobiology of this disorder. The eight known metabotropic glutamate receptors (mGluRs) are divided into three groups on the basis of sequence homology and pharmacological properties. Group I consists of mGluR5 and mGluR1, both of which are coupled positively to… CONTINUE READING


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