Disruption of plastid acyl:acyl carrier protein synthetases increases medium chain fatty acid accumulation in seeds of transgenic Arabidopsis.

@article{Tjellstrm2013DisruptionOP,
  title={Disruption of plastid acyl:acyl carrier protein synthetases increases medium chain fatty acid accumulation in seeds of transgenic Arabidopsis.},
  author={Henrik Tjellstr{\"o}m and Merissa Strawsine and J. Machado Silva and Edgar B Cahoon and John B. Ohlrogge},
  journal={FEBS letters},
  year={2013},
  volume={587 7},
  pages={
          936-42
        }
}
Engineering transgenic plants that accumulate high levels of medium-chain fatty acids (MCFA) has been least successful for shorter chain lengths (e.g., C8). We demonstrate that one limitation is the activity of acyl-ACP synthetase (AAE) that re-activates fatty acids released by acyl-ACP thioesterases. Seed expression of Cuphea pulcherrima FATB acyl-ACP thioesterase in a double mutant lacking AAE15/16 increased 8:0 accumulation almost 2-fold compared to expression in wild type. These results… CONTINUE READING
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