Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization.

@article{Phillips2007DisruptionOP,
  title={Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization.},
  author={Helen M. Phillips and Hong Jun Rhee and Jennifer N. Murdoch and Victoria Hildreth and Jonathan D Peat and Robert H. Anderson and Andrew J Copp and Bill Chaudhry and Deborah J Henderson},
  journal={Circulation research},
  year={2007},
  volume={101 2},
  pages={137-45}
}
The Drosophila scribble gene regulates apical-basal polarity and is implicated in control of cellular architecture and cell growth control. Mutations in mammalian Scrib (circletail; Crc mutant) also result in abnormalities suggestive of roles in planar cell polarity regulation. We show that Crc mutants develop heart malformations and cardiomyopathy attributable to abnormalities in cardiomyocyte organization within the early heart tube. N-Cadherin is lost from the cardiomyocyte cell membrane and… CONTINUE READING

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Biophysical mechanisms of cardiac looping.

The International journal of developmental biology • 2006

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