Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.

@article{Tanaka2012DisruptionOP,
  title={Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.},
  author={Naoki Tanaka and Tsutomu Matsubara and Kristopher W. Krausz and Andrew D. Patterson and Frank J. Gonzalez},
  journal={Hepatology},
  year={2012},
  volume={56 1},
  pages={118-29}
}
UNLABELLED Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease that can develop into cirrhosis, hepatic failure, and hepatocellular carcinoma. Although several metabolic pathways are disrupted and endogenous metabolites may change in NASH, the alterations in serum metabolites during NASH development remain unclear. To gain insight into the disease mechanism, serum metabolite changes were assessed using metabolomics with ultraperformance liquid… CONTINUE READING