Disruption of p53 in human cancer cells alters the responses to therapeutic agents.

@article{Bunz1999DisruptionOP,
  title={Disruption of p53 in human cancer cells alters the responses to therapeutic agents.},
  author={Fred Bunz and Paul M. Hwang and Colin Torrance and Todd Waldman and Yuzhi Zhang and Larry E. Dillehay and Jerry R. Williams and Christoph Lengauer and Kenneth W. Kinzler and Bert Vogelstein},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={104 3},
  pages={263-9}
}
We have examined the effects of commonly used chemotherapeutic agents on human colon cancer cell lines in which the p53 pathway has been specifically disrupted by targeted homologous recombination. We found that p53 had profound effects on drug responses, and these effects varied dramatically depending on the drug. The p53-deficient cells were sensitized to the effects of DNA-damaging agents as a result of the failure to induce expression of the cyclin-dependent kinase inhibitor p21. In… CONTINUE READING
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