Disruption of oxygen-regulated responses underlies pathological changes in the placentas of women who smoke or who are passively exposed to smoke during pregnancy.

@article{Genbacev2003DisruptionOO,
  title={Disruption of oxygen-regulated responses underlies pathological changes in the placentas of women who smoke or who are passively exposed to smoke during pregnancy.},
  author={Olga D Genbacev and Michael T Mcmaster and Tamara Zdravkovic and Susan J. Fisher},
  journal={Reproductive toxicology},
  year={2003},
  volume={17 5},
  pages={509-18}
}
Previously, we showed that maternal smoking harms human placental development by changing the balance between cytotrophoblast (CTB) proliferation and differentiation. To understand the mechanisms involved, we studied the effects of maternal smoking and in vitro exposure of CTBs to nicotine and on CTB expression of molecules that govern cellular responses to oxygen tension: the von Hippel-Lindau tumor suppressor protein (pVHL), the hypoxia-inducible transcription factors (HIFs), and the vascular… CONTINUE READING

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